• Nowadays colorimetric assay has been applied

  2021-01-15

  

  Nowadays, colorimetric assay has been applied in detecting DNA MTase activity. Li et al. used DNA modified gold nanoparticles (AuNPs) coupled with enzyme-linkage reactions to detect the activity of methylases [20]. In a previous study, our group presented a label-free colorimetric method, using unmo

• Because of the complexity of DNA damage and its

  2021-01-15

  

  Because of the complexity of DNA damage and its repair, several pathways are candidates in HN2-induced DPC repair. Considering the 23kDa molecular weight of MGMT, NER may be ineffective for MGMT-adduct removal. This presumption is supported by that the mRNA level of ERCC1, a core gene in NER pathway

• Therefore in this study we determined whether

  2021-01-15

  

  Therefore, in this study we determined whether exogenous LTD, a potent agonist of both CysLT and CysLT receptors , , induces Bleomycin A5 hydrochloride edema and AQP4 expression in mouse brain; if so, which subtype of the receptors is involved in AQP4 expression in mouse brain and the cultured rat

• In summary the loss of seven Cyp

  2021-01-15

  

  In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to

• Although intact Chk is distributed throughout the

  2021-01-15

  

  Although intact Chk is distributed throughout the nucleus and the cytoplasm (Fig. 1), the deletion of the SH2 domain greatly augments nuclear localization of Chk. The SH2 domain-deleted mutants might lose the ability to localize to the exterior of the nucleus due to a lack of the binding to a hypoth

• br Most reported binding data are obtained by performing het

  2021-01-15

  

  Most reported binding data are obtained by performing heterologous competition binding experiments and expressing the results as relative binding affinity (RBA). The constructed binding curves should theoretically be sigmoidal in shape with a Hill slope value of one, for a single ligand binding t

• RHA is an agricultural by

  2021-01-15

  

  RHA is an agricultural by-product obtained from the burning process of rice hull [7], [8]. Rice hull is the outer layer of paddy grain. About 20% of rice hull converts into RHA when it is burnt during the MnTBAP Chloride receptor generation processes [8], [9]. If RHA produced at less than 700 °C, i

• Our study revealed elevated basal Akt phosphorylation

  2021-01-14

  

  Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti

• There are five phosphorylated serines in casein

  2021-01-14

  

  There are five phosphorylated serines in β-casein. However, only phosphorylated Ser35 was identified in the samples hydrolysed with GE at 37 and 50 °C, i.e., f32-42 and f32-44 of β-casein. The identification indicates that phosphorylated peptides were less detectable from the non-phosphorylated pept

• In humans several different small ubiquitin related modifier

  2021-01-14

  

  In humans, several different small ubiquitin-related modifier (SUMO) paralogs can be conjugated to cellular proteins. The human genome codes for five SUMO paralogs (SUMO1–5); of these, SUMO1 and the almost identical SUMO2 and SUMO3 are ubiquitously expressed. Sumoylation is executed by an enzymatic

• br Conflicts of interest br Introduction G protein coupled

  2021-01-14

  

  Conflicts of interest Introduction G protein-coupled receptors (GPCRs), form the largest human membrane protein family, with 800 members overall. Many druggable targets for treatment of common diseases involve GPCRs that mediate therapeutic effects of 34% of all marketed drugs (Hauser, Attwood

• DNA damage represents a persistent threat to genomic

  2021-01-14

  

  DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS

• UCF 101 Hedamycin isolated from Streptomyces griseoruber bel

  2021-01-14

  

  Hedamycin, isolated from Streptomyces griseoruber, belongs to the highly cytotoxic pluramycin class of UCF 101 (Figure 3(c)). It consists of a planar anthrapyrantrione chromophore attached to two amino sugar rings at one end and a bisepoxide-containing side-chain at the other end (Figure 3(c)). Hed

• CysLTs trigger contractile and inflammatory processes throug

  2021-01-14

  

  CysLTs trigger contractile and inflammatory processes through the specific interaction with cell surface receptors belonging to the rhodopsin family of the G protein-coupled receptor (GPCR) genes. Until now, two receptor subtypes have been cloned, namely CysLT1 and CysLT2[8]. In particular, when the

• The sex dimorphic expression of mouse CYP A is partially

  2021-01-14

  

  The sex-dimorphic Methylcobalamin of mouse CYP3A is partially due to sex-dimorphic plasma GH profile which is a decisive factor in the regulation of sexspecific CYP isoforms [14]. Nevertheless, in our study we did not observe any changes in plasma GH levels in either mouse sex with a selective abla

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