• FOX proteins constitute a large class of transcription facto

  2020-09-21

  

  FOX proteins constitute a large class of transcription factors with multiple functions, from development and organogenesis to regulation of metabolic and immune functions. The Fox transcription factor is characterized by a 100-amino-acid wing helix or forkhead DNA-binding domain. In addition, the FO

• cGAS has a central role in

  2020-09-21

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• P falciparum DHFR TS is a particularly important enzyme

  2020-09-21

  

  P. falciparum DHFR-TS is a particularly important enzyme, because it is from the protozoan species that is associated with most malaria infections. Since this enzyme is responsible for catalyzing sequential reactions in the thymidylate cycle, its inhibition slows malarial dTMP production and therefo

• Studies of LRRK tagged with green fluorescent protein reveal

  2020-09-21

  

  Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the Cy5 NHS ester of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines its f

• Interaction between neutrophils and ECs represents

  2020-09-21

  

  Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that

• Another breakthrough towards the understanding

  2020-09-19

  

  Another breakthrough towards the understanding of the mechanisms responsible for stress-induced relapse to drug seeking behaviour is the evidence published by the group of Wise [34] in which they show that the activation of VTA CRF2 and not CRF1 receptors is responsible for stress-mediated relapse t

• Riboflavin According to this theory the chemical potential

  2020-09-19

  

  According to this theory, the chemical potential of the basic hydrate in the equilibrium condition can be calculated as: , and denote the chemical potentials of the basic hydrate, water and gas, respectively. Also, is the number of gas molecules per water molecules in the basic hydrate. After su

• The small intestine is the

  2020-09-19

  

  The small intestine is the only organ responsible for the Sulbactam of dietary and biliary cholesterol, leaving the unabsorbed cholesterol to be excreted in feces and together contributing to the body cholesterol homeostasis [13], [21], [33], [34]. Following intraluminal hydrolysis, free cholesterol

• Replacement of the saturated propoxy group in compound with

  2020-09-19

  

  Replacement of the saturated -propoxy group in compound with the unsaturated allyloxy group to obtain compound resulted in 10-fold decrease in ET receptor antagonism and more than 20-fold decrease in ET-selectivity. Analogous unsaturated allyloxy compound in the tetrazole series was found to have di

• We report our experience using conventional cytogenetic anal

  2020-09-19

  

  We report our experience using conventional cytogenetic analysis, FISH using EWSR1 break-apart probes, RT-PCR, and Sanger sequencing to detect characteristic translocations in a total of 32 patients with ES diagnosed at Texas Children\'s Hospital over a 5-year interval. Materials and methods R

• br Transparency document br Acknowledgments This study was

  2020-09-19

  

  Transparency document Acknowledgments This study was funded by ICMR, Govt. of India. Alisha Dhiman acknowledges UGC-DSKPDF, India for post-doctoral fellowship and Monisha Gopalani acknowledges CSIR, India for Senior Research Fellowship. AIRF, JNU is acknowledged for TEM, confocal microscopy an

• br Conflict of interest br Introduction Endothelin receptors

  2020-09-19

  

  Conflict of interest Introduction Endothelin receptors are members of the superfamily of G-protein-coupled receptors (GPCRs) and central regulators of vascular tension and other physiological functions in higher eukaryotes [1]. The human endothelin system comprises the highly homologous endoth

• Although many of the hepatic responses observed

  2020-09-18

  

  Although many of the hepatic responses observed on the first day of recovery attenuated over the course of the recovery period, minimal-to-mild centrilobular hepatocellular hypertrophy tended to persist. Mean absolute and relative liver weights had returned to control levels after 28 days of recover

• From a mechanistic standpoint the

  2020-09-18

  

  From a mechanistic standpoint, the BCL6 RD2 domain represses the GPR183 and S1PR1 loci by recruiting HDAC2, but not MTA3-NuRD, to suppress the enhancer activation mark H3K27ac at their distal regulatory elements. However, these data do not exclude the possibility that other as yet unknown corepresso

• In mice our EBI EGFP reporter showed that

  2020-09-18

  

  In mice, our EBI2EGFP reporter showed that EBI2 is expressed consistently in naive T helper cells. Already single positive CD4+ thymocytes express EBI2 (not shown). In effector and regulatory T cells in naive mice, the percentage of EBI2 expression was lower (∼40%). Like others (Liu et al., 2011), w

16318 records 807/1088 page Previous Next First page 上5页 806807808809810 下5页 Last page