• PRX-08066 Renal injury by cisplatin has been associated with

  2020-07-29

  

  Renal injury by cisplatin has been associated with oxidative stress, inflammation, and apoptosis (Francescato et al., 2007, Iseri et al., 2007, Kiymaz et al., 2008, Ueki et al., 2012). Specifically, apoptosis is an important mode of cell death in cisplatin nephrotoxicity, and many studies including

• er alpha For the series of arylchromenone ones bearing small

  2020-07-28

  

  For the series of arylchromenone-4-ones bearing small -alkoxy substituents at the phenyl 3-position (, –), it is evident that substitution improved neither activity nor selectivity compared with the dibenzothiophenyl analogue . Overall, a 6- to 12-fold reduction in potency was observed, and with th

• Bim is a Bcl homology BH

  2020-07-28

  

  Bim is a Bcl-2 homology-3 (BH-3) only pro-apoptotic Bcl-2 family member. Alternative splicing of Bim mRNA results in three isoforms: BimEL, BimL and BimS (O’Connor et al., 1998). Cells with low level of Bim expression are resistant to death induction, and Bim overexpression sensitizes cells to death

• A series of former studies provided preliminary

  2020-07-28

  

  A series of former studies provided preliminary indirect evidence that the nucleo-cytoplasmic transport of mRNAs encoding CD83 may be specifically regulated in DC. For example, the cytoplasmic accumulation of a small subset of cellular transcripts, including CD83 mRNA, appears to depend on a functio

• We have also shown that knockdown of the SR protein

  2020-07-28

  

  We have also shown that knockdown of the SR protein 9G8 in the larval fat body also leads to a decreased triglyceride storage phenotype. Surprisingly, the knockdown of 9G8 in the adult female fat body resulted in a large increase in triglyceride levels and this is mainly due to an increase in the a

• br Conclusion The SO effects

  2020-07-28

  

  Conclusion The SO effects on the anion photoelectron spectra of Ln(COT)2− (Ln=Ce-Yb) were systematically investigated by the SO-MCQDPT2 method. Although the SO interaction has a significant effect on the electronic structures of the Ln portion, it is qualitatively insignificant for the VDEs and m

• The present results are potentially relevant

  2020-07-28

  

  The present results are potentially relevant for understanding anxiety disorders and their treatment. Both COMT Val158Met (Lonsdorf and Kalisch, 2011, Montag et al., 2012) and neuroticism/anxiety (Clark et al., 1994, Mineka et al., 1998, Weinstock and Whisman, 2006) have been linked to the prevalenc

• In this clinical context measures of cell mediated

  2020-07-28

  

  In this clinical context, measures of cell-mediated immune response to CMV have been evaluated. The QuantiFERON-CMV assay (QFN-CMV; Qiagen, Germany) which measures predominantly CD8+ T-cell responses to CMV by an in-tube IFN-gamma release technique is commercially available in some regions.1, 2 Con

• The genetic basis of non FH is

  2020-07-28

  

  The genetic basis of non-FH is a relevant and controversial issue. In two different whole exome sequencing in ADH patients negative for LDLR/APOB/PCSK9 mutations [26] and individuals selected for extreme LDL cholesterol (>98th percentile) [27] no major novel locus for FH was detected. A new locus at

• br Author Contributions br Funding Canadian Institutes of

  2020-07-28

  

  Author Contributions Funding Canadian Institutes of Health Research, operating grant NMD-83126 and the internal funding from the National Research Council Canada, Charlottetown, PE, Canada. Disclosure Statement Acknowledgements Introduction Cholesterol is an essential structural comp

• This integration of DA and glutamate

  2020-07-27

  

  This integration of DA and glutamate inputs is mainly accomplished by the Medium-sized Spiny GABAergic Neurons (MSN), which receive glutamate axon terminals and DA afferences converging on MSN dendritic spines (Moss and Bolam, 2008; Doig et al., 2010). MSN form primarily two segregated populations b

• The mechanism of HP remains to

  2020-07-27

  

  The mechanism of HP remains to be elucidated, irrespective of idiopathic or secondary type. The HP dura shows infiltration of a variety of inflammatory gpr55 agonist and interstitial fibrosis (Bosman et al., 2008; Hassan et al., 2011). Because components of the inflammatory process facilitate or att

• br Materials and methods br Results br Discussion br

  2020-07-27

  

  Materials and methods Results Discussion Acknowledgements We thank P.J. Focia and Z. Wawrzak for support in data collection and S. Gomes for support in generating IL-34 mutant clones. X.H. is supported by the NIH grant 1R01GM078055. The Structural Biology Facility is supported by the R.H

• br Acknowledgements This work was supported by a Biotechnolo

  2020-07-27

  

  Acknowledgements This work was supported by a Biotechnology and Biological Sciences Research Council Industrial Case Studentship (BB/I015965/1) awarded to AMD and PD. The authors wish to thank M. Chow for helpful discussions, I. Prokes (University of Warwick, Coventry, UK) for NMR assistance, and

• br Materials and methods br Results

  2020-07-27

  

  Materials and methods Results Discussion Chicken thrombocyte stimulation with LPS leads to a number of inflammatory responses through TLR4-linked pathways (Scott and Owens, 2008). In mammals, LPS binds to LPS-binding protein (LBP) in the blood serum and this complex is subsequently recogniz

16418 records 836/1095 page Previous Next First page 上5页 836837838839840 下5页 Last page