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CFSs are recognized as a driver of genome
2019-08-07
CFSs are recognized as a driver of genome instability in human cells and are hotspots for deletions or translocations in cancers (Richards, 2001). The generally accepted model for their expression is that the CFS locus shows a delay in chromatin condensation in early mitosis caused by the persistenc
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To overcome problems with the
2019-08-07
To overcome problems with the biochemical reconstitution of these heterodimeric cytokines fusion strategies linking both subunits together have been proposed inspired by the “hyper-IL-6” [28]. Much like fusing a protein to a solubility enhancing protein such as MBP or SUMO, fusing two subunits of a
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br Conclusions Present work comprehensively characterizes th
2019-08-07
Conclusions Present work comprehensively characterizes the inhibitory activity of Yersinia enterocolitica against cysteine proteases. All tested strains, regardless of their bioserotype, genotype and the presence of virulence markers, synthesized the high-molecular-weight inhibitors of papain and
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br CXCR The CXC receptor and
2019-08-07
CXCR1/2 The CXC receptor 1 and 2 (CXCR1 and CXCR2) have been well characterised in vertebrates. In mammals and birds, the two receptors are shared by the ELR+ CXC ligands, namely the CXCL8 family members that have proinflammatory roles in recruitment of neutrophils, monocytes and macrophages to s
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We then explored the potential roles of
2019-08-07
We then explored the potential roles of vigilin, along with other proteins which have affinity for the 69 nt CSF-1R element, in breast cancer cells. The sequestration of these proteins by excess 69 nt pyrimidine-rich element increases CSF-1R levels (Figures 2 and 4), and as a result, increases the d
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The CRTH inhibitory activities of the synthesized compounds
2019-08-07
The CRTH2 inhibitory activities of the synthesized compounds are listed in , . At first we introduced halogen or other substituents at the 4,4′-position of phenyl rings in the benzhydryl moiety in order to obtain SAR and to improve the metabolic stability at this moiety (–). It is well-known that in
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In a previous study we reported that the systemic
2019-08-07
In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in LIMKi 3 reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to investig
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TPCA-1 The proposed FDIR technique is presented in
2019-08-07
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the TPCA-1 environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimated is prese
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br Experimental protocols br Acknowledgements This research
2019-08-07
Experimental protocols Acknowledgements This research was funded by the Croatian Ministry of Science, Education and Sports (Programmes 098-0982915-2948 and 098-0982522-2525), the Austrian Science Fund FWF (DK-MCD W1226, SFB LIPOTOX F30, P22832), and the Croatian-Austrian Intergovernmental S&T
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To ascertain that the slower
2019-08-07
To ascertain that the slower migrating bands represented phosphorylated CDK5, we performed a phosphatase assay. Lysates of Patchouli alcohol co-expressing p35 and either WT or D144N CDK5 were immunoprecipitated using an anti-p35 antibody. The immunoprecipitates were then dephosphorylated using SAP
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Fmoc-Gln(Trt)-OH reviews The goal of this paper is to invest
2019-08-06
The goal of this Fmoc-Gln(Trt)-OH reviews paper is to investigate the penalized empirical likelihood method for the Cox model, as a competitor to the penalized partial likelihood. Since empirical likelihood (EL) was proposed by Owen, 1988, Owen, 2001, empirical likelihood methods have been investig
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Even minor alterations in the surfactants structure could ha
2019-08-06
Even minor alterations in the surfactants structure could have consequences on their physico-chemical characteristics; mono-RLs have less solubility, stronger surfaces sorb, and stronger cationic metals binding than homologue di-RLs (Zhang et al., 1997). The HPLC separation of RLs structure is base
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br Introduction Concrete is one of the
2019-08-06
Introduction Concrete is one of the most commonly used materials in the construction industry and its raw material is available throughout the world. Concrete is derived from ordinary Portland cement and is used for the construction and development of infrastructures. Research shows that demand f
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br STAR Methods br Acknowledgments We thank
2019-08-06
STAR★Methods Acknowledgments We thank members of R.L. lab and F. Schweisguth for critical reading of the manuscript. We are also grateful to F. Janody, M. Miura, C. Bökel, H.D. Ryoo, G. Jiménez, the Bloomington Drosophila Stock Center, the Drosophila Genetic Resource Center, the Vienna Drosop
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br Concluding remarks br Transparency document br Acknowledg
2019-08-06
Concluding remarks Transparency document Acknowledgements Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA033572 (RS). The content is solely the responsibility of the authors and does not neces
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