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order 740 Y-P Introduction The stem cells extracted from the
2018-11-08
Introduction The stem cells extracted from the inner cell mass of an embryo are pluripotent, i.e. they have unique ability of long-term self-renewal and the potential to develop into all specialized cell types (Evans and Kaufman, 1981; Martin, 1981). However, embryonic stem cells with different ori
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br Materials and methods br Acknowledgments We
2018-11-08
Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the plasmids for reprogramming. We thank Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Mehri Mirrajei for cytogenetic technical assistanc
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In this study we transplanted human
2018-11-08
In this study, we transplanted human iHeps into the livers of Gunn rats. Proliferation of the transplanted Sorafenib was induced by preconditioning a single liver lobe by hepatic X-irradiation (HIR). HIR enhances the engraftment of transplanted cells by transiently disrupting the sinusoidal endothel
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br Results br Discussion The pluripotency
2018-11-08
Results Discussion The pluripotency status of ES abacavir or iPS cells is maintained by a tightly regulated transcription factor network (Boyer et al., 2005). OCT4 is at the center of this network (Pardo et al., 2010; van den Berg et al., 2010) and is associated with chromatin modifiers to ma
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br Results br Discussion A series of studies
2018-11-08
Results Discussion A series of studies has reported that TBX3 was indispensable for maintenance of pluripotency. In line, TBX3 gain of function facilitated induction of pluripotency (Han et al., 2010a; Ivanova et al., 2006; Lee et al., 2012; Lu et al., 2011; Nishiyama et al., 2013) but interes
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cevimeline Our initial endeavors in characterizing our isoge
2018-11-08
Our initial endeavors in characterizing our isogenic iPSCs lines included a microarray-based large-scale gene cevimeline analysis comparing the HD iPSCs with the corrected line C116 iPSCs (An et al., 2012). These studies were restricted to a comparison of only the iPSCs lines but yielded several us
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Recently profound therapeutic efficacy of intratracheally tr
2018-11-08
Recently, profound therapeutic efficacy of intratracheally transplanted bone marrow-derived Mφ has been demonstrated in two murine disease models of herPAP, indicating a therapeutic potential also of iPSC-derived Mφ (Happle et al., 2014; Suzuki et al., 2014a). In this context genetically repaired hu
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In the present study we aimed to establish a combination
2018-11-07
In the present study, we aimed to establish a combination therapy approach composed of cellular replacement by ESC-derived neural progenitors linked to BDNF supply. For this reason, we have generated BDNF-overexpressing mouse ESCs by knockin technology that display an enhanced neuronal and GABAergic
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Intramural sports and a cappella singing groups were
2018-11-07
Intramural sports and a cappella singing groups were also common at Yale, as at many other institutions. The best known of the singing groups was the Whiffenpoofs. About 15% of the class were members of such groups, and 48% participated in intramural athletics. Results As displayed in Table 1, s
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While the mechanisms by which hemoglobinopathies confer mala
2018-11-07
While the mechanisms by which hemoglobinopathies confer malaria protection are debated (), with the notable exception of HbAS, they do not seem to protect by suppressing parasite densities. Epidemiological observations, together with in-vitro data, support alternative mechanisms of protection that e
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From a translational standpoint TSCM cells emerge as most
2018-11-07
From a translational standpoint, TSCM galanin emerge as most promising population for immunotherapy. In this regard, recent reports which indicate that the efficacy of CAR T cells might be based on their acquisition of a TSCM cell phenotype are highly encouraging (Yang et al., 2014); however, previ
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The high burden of ocular disease in CKD can be
2018-11-07
The high burden of ocular disease in CKD can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to CKD via common pathogenic pathw
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The following are the supplementary data related to
2018-11-07
The following are the supplementary data related to this article. Disclosure of Potential Conflict of Interest Author Contributions The study was designed by SK, JR, ISC, HL, CR, and SAL. DNA extraction and PCRs (polA, tp47, tp0548, and ITS-2) were performed at the laboratory of the German Pr
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High oxidative stress and DNA damage activity are increased
2018-11-07
High oxidative stress and DNA damage activity are increased, while the anti-oxidant enzyme levels are decreased in MM patients (Mehdi et al., 2013). Several free radical drugs, such as As2O3 and ascorbic acid, have been used to treat MM, in which As2O3 generates ROS while ascorbic mao inhibitor serv
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protease inhibitor cocktail NAbs occurring after initial inf
2018-11-07
NAbs occurring after initial infection with HIV-1 are generally not associated with any clinical or biological benefits. Doria-Rose et al. (2010) suggested that the limited breadth of neutralization observed in whole-serum samples from LTNP patients maybe attributable to low levels of antigenic stim
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