• br Results br Discussion A series of studies

  2018-11-08

  

  Results Discussion A series of studies has reported that TBX3 was indispensable for maintenance of pluripotency. In line, TBX3 gain of function facilitated induction of pluripotency (Han et al., 2010a; Ivanova et al., 2006; Lee et al., 2012; Lu et al., 2011; Nishiyama et al., 2013) but interes

• cevimeline Our initial endeavors in characterizing our isoge

  2018-11-08

  

  Our initial endeavors in characterizing our isogenic iPSCs lines included a microarray-based large-scale gene cevimeline analysis comparing the HD iPSCs with the corrected line C116 iPSCs (An et al., 2012). These studies were restricted to a comparison of only the iPSCs lines but yielded several us

• Recently profound therapeutic efficacy of intratracheally tr

  2018-11-08

  

  Recently, profound therapeutic efficacy of intratracheally transplanted bone marrow-derived Mφ has been demonstrated in two murine disease models of herPAP, indicating a therapeutic potential also of iPSC-derived Mφ (Happle et al., 2014; Suzuki et al., 2014a). In this context genetically repaired hu

• In the present study we aimed to establish a combination

  2018-11-07

  

  In the present study, we aimed to establish a combination therapy approach composed of cellular replacement by ESC-derived neural progenitors linked to BDNF supply. For this reason, we have generated BDNF-overexpressing mouse ESCs by knockin technology that display an enhanced neuronal and GABAergic

• Intramural sports and a cappella singing groups were

  2018-11-07

  

  Intramural sports and a cappella singing groups were also common at Yale, as at many other institutions. The best known of the singing groups was the Whiffenpoofs. About 15% of the class were members of such groups, and 48% participated in intramural athletics. Results As displayed in Table 1, s

• While the mechanisms by which hemoglobinopathies confer mala

  2018-11-07

  

  While the mechanisms by which hemoglobinopathies confer malaria protection are debated (), with the notable exception of HbAS, they do not seem to protect by suppressing parasite densities. Epidemiological observations, together with in-vitro data, support alternative mechanisms of protection that e

• From a translational standpoint TSCM cells emerge as most

  2018-11-07

  

  From a translational standpoint, TSCM galanin emerge as most promising population for immunotherapy. In this regard, recent reports which indicate that the efficacy of CAR T cells might be based on their acquisition of a TSCM cell phenotype are highly encouraging (Yang et al., 2014); however, previ

• The high burden of ocular disease in CKD can be

  2018-11-07

  

  The high burden of ocular disease in CKD can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to CKD via common pathogenic pathw

• The following are the supplementary data related to

  2018-11-07

  

  The following are the supplementary data related to this article. Disclosure of Potential Conflict of Interest Author Contributions The study was designed by SK, JR, ISC, HL, CR, and SAL. DNA extraction and PCRs (polA, tp47, tp0548, and ITS-2) were performed at the laboratory of the German Pr

• High oxidative stress and DNA damage activity are increased

  2018-11-07

  

  High oxidative stress and DNA damage activity are increased, while the anti-oxidant enzyme levels are decreased in MM patients (Mehdi et al., 2013). Several free radical drugs, such as As2O3 and ascorbic acid, have been used to treat MM, in which As2O3 generates ROS while ascorbic mao inhibitor serv

• protease inhibitor cocktail NAbs occurring after initial inf

  2018-11-07

  

  NAbs occurring after initial infection with HIV-1 are generally not associated with any clinical or biological benefits. Doria-Rose et al. (2010) suggested that the limited breadth of neutralization observed in whole-serum samples from LTNP patients maybe attributable to low levels of antigenic stim

• Individual pharmacokinetic parameters for d BPA

  2018-11-07

  

  Individual pharmacokinetic parameters for d6-BPA, d6-BPAS, d6-BPAG and d6-total BPA are presented in Supplementary Tables 5, 6, 7 and 8 respectively. Experimental design, materials and methods Specifications table Value of the data Experimental design, materials and methods Statistica

• br Methods br Results br Discussion The results of

  2018-11-07

  

  Methods Results Discussion The results of the current study demonstrate that regardless of whether adolescents were exposed to ethanol in early or late adolescence, animals that received binge-like exposure to alcohol during adolescence exhibited notable long-lasting attenuations in the ave

• Notable strengths of the study include acquisition of spectr

  2018-11-07

  

  Notable strengths of the study include acquisition of spectral data through the use of 2D-JPRESS at 4.0T, which permits improved spatial and spectral resolution, high SNR afforded by high field MRS, and optimal detection of Glu separately from Gln. However, it should be noted that the MRS technique

• One concept in developmental neuroscience that resonates wit

  2018-11-07

  

  One concept in developmental neuroscience that resonates with stage approaches common in developmental psychology is that of sensitive or critical maturational periods. In this approach, PCI32765 and behavioral organization are considered particularly amenable to specific types of information durin

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