• br Case report A year old man with

  2019-07-01

  

  Case report A 50-year-old man with no known systemic diseases presented to our facility with a growing huge mass at his left flank and numbness of the left leg. Five years earlier, there was only a small lump over his left flank. However, the soft tissue lesion gradually enlarged, accompanied by

• NCT-502 Introduction Despite advances in breast cancer treat

  2019-07-01

  

  Introduction Despite advances in breast cancer treatment, bone remains the most common site of NCT-502 [1,2] occurring in around 70% of patients with metastatic disease [3]. Bone metastases are incurable and associated with significant morbidity in terms of fractures, pain, and reduced quality of

• beta adrenergic blockers Given the recognized effects of bis

  2019-07-01

  

  Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and beta adrenergic blockers based-studies [19,20] a number o

• br Conflict of interest br Authors contributions

  2019-07-01

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• The majority of breast malignancies are hormone responsive a

  2019-07-01

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• In this case series no

  2019-07-01

  

  In this case series, no clinical thromboembolic events were detected in a cohort with a mean CHA2DS2-VASc score of 2.6 ±1 over a follow-up time of up to 5 years. The overall stroke rate was 0.5% per year. The authors concede that the very low stroke rate could have been the outcome of successful abl

• It means an opportunity As we concern ourselves with

  2019-07-01

  

  It means an opportunity. As we concern ourselves with the prominence of health in the new agenda, it\'s easy to forget that (human) development is by definition people-centred, and that living a long, healthy, and creative life is its cornerstone. The expansion of the new goals to encompass many (if

• Por lo dem s resulta sugerente asociar la

  2019-06-29

  

  Por lo demás, resulta sugerente asociar la expansión de la antología con el traslado de Gutiérrez Bexarotene Chile, donde se instala en 1845- De los “cuyanos” (mote con que se conocía a los argentinos), dice Ricardo Rojas: Esta nota sirve a los fines de enfatizar la potencia y el vigor intelectual

• In patients with ovary lesions surgical intervention play an

  2019-06-29

  

  In patients with ovary lesions, surgical intervention play an important role to establish correct diagnosis. First of all, obtaining histologic confirmation of disease by laparotomy is critical in differentiating primary ovarian cancer between metastatic lesions such as gastric cancer to the ovary (

• Las formas literarias de presentaci

  2019-06-29

  

  Las formas literarias de presentación de los textos aquí comentados son distintas: estamos frente a una obra de teatro, dos artículos (o capítulos de libro) y un cuento. El establecimiento de una ‘periodización’ de la historia de la literatura mexicana a partir de cuatro etapas —la prehispánica,

• br La historia de los animales en el Nuevo

  2019-06-29

  

  La historia de los animales en el Nuevo Mundo La descripción de la NB-598 hydrochloride americana fue una tarea que realizaron algunos exploradores, soldados, funcionarios y religiosos como respuesta a la petición de información de las autoridades, deseosas de conocer la fauna y descubrir las pr

• Al observar las cuatro constituciones

  2019-06-29

  

  Al observar las cuatro constituciones (Brasil, Argentina, Paraguay y Uruguay) se destaca una ejemplar redacción del Artículo 47 de la Constitución de Uruguay, al definir cuál es la prioridad en el uso del recurso además de determinar no sólo la participación social en la planificación de estrategias

• Ya se alamos l neas arriba que el elogio

  2019-06-29

  

  Ya señalamos líneas arriba que el elogio respondía fructose 1 6 bisphosphatase una tradición primordialmente masculina. Ese rasgo se reproduce, claro está, en la RF, lo cual se explica fácilmente por las redes de sociabilidad que nutrían a esta revista y que esbozamos al principio de este artículo.

• ITE structure We established Wt and two

  2019-06-29

  

  We established Wt- and two Mt- (p.R308P and p.A350_N351ins8)-GATA2-expressing 32D ITE structure to analyze the cellular effects of Mt-GATA2 (Fig. 3A). Immunofluorescence analysis revealed that Mt-GATA2 showed similar localization in the nucleus as Wt-GATA2 (Fig. 3B). Both Wt- and mutant-GATA2-expre

• br Acknowledgements br Introduction The chronic myeloprolife

  2019-06-29

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

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