• lcz696 Whereas binding of activated RhoA to

  2021-10-26

  

  Whereas binding of activated RhoA to the PH domains of the RhoGEFs is proposed to mediate positive feedback regulation (Chen et al., 2010b, Medina et al., 2013), the sequestration of p190RhoGEF by activated Rac1 reveals a novel putative physiological role, that is to utilize Rac1 to directly drive r

• Decreased ratio of Treg TH is reported to

  2021-10-26

  

  Decreased ratio of Treg/TH17 is reported to correlate with MS disease severity [63]. Treg enfuvirtide are the major anti-inflammatory subset of T cells which suppress proinflammatory T-cells by producing anti-inflammatory cytokines, such as IL-10 and TGF-β, as well as play a critical role in mainta

• br Conclusion br Conflict of Interest

  2021-10-26

  

  Conclusion Conflict-of-Interest JJH has collaborated with several different pharmaceutical companies during the last 30 years; is currently receiving speaker honoraria from NovoNordisk and MSD and is on advisory boards for NovoNordisk. The author is currently supported by an independent grant

• Dysregulation of the HPA axis resulting in alteration to

  2021-10-25

  

  Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba

• On the other hand after injury of the

  2021-10-25

  

  On the other hand, after injury of the adult heart, inflammatory monocytes are abundantly recruited to damaged myocardium and they differentiate into monocyte-derived macrophages (MDMs). They have strong proinflammatory phenotype and very limited capacity to promote angiogenesis and cardiomyocyte pr

• br Disp Cleavage and Membrane Trafficking Knowledge of how D

  2021-10-25

  

  Disp Cleavage and Membrane Trafficking Knowledge of how Disp is regulated in Shh-producing KPT-9274 receptor to control ligand deployment has, until recently, remained limited. Early studies examining Disp function in Madin–Darby Canine Kidney (MDCK) cells and Drosophila tissue suggested that it

• Recent studies have indicated that

  2021-10-25

  

  Recent studies have indicated that HDAC and BRD4 are associated with similar biological phenotypes related to cancer and combination of the HDAC inhibitor LBH589 and BET inhibitor I-BET151 synergistically induces apoptosis of melanoma cells [20], [21]. Moreover, combination of Panobinostat and (+)-J

• HCV is a highly diverse

  2021-10-25

  

  HCV is a highly diverse virus with seven known genotypes (GT1–7) and multiple subtypes (Gower et al., 2014, Messina et al., 2015, Smith et al., 2014). Patients infected with HCV develop a heterogeneous population of viral species known as quasispecies due to low fidelity of the RNA-dependent RNA pol

• CONUT score is an effective detector

  2021-10-25

  

  CONUT score is an effective detector of predicting OS and RFS in HCC patients. We found that patients with a damaged immune-nutrition status had significantly poor OS and RFS. Our initial literature review also retrieved other studies evaluating the survival of HCC patients using CONUT score [36,48,

• br Concluding remarks Several orphan GPCRs have expression

  2021-10-25

  

  Concluding remarks Several orphan GPCRs have expression profiles that indicate they are worthy of consideration as therapeutic targets. This view can be supported via various transgenic techniques, and it would be interesting to have wide-ranging phenotypic information on GPR35 knockout mice. Bas

• In both families GPR A mRNA

  2021-10-25

  

  In both families, GPR109A mRNA in kidney fat was positively correlated with NEFA as a tendency. A positive correlation between this fat depot and insulin was observed in lean-type cows. In fat-type cows, mesenteric GPR109A mRNA correlated positively with insulin and negatively with urea on a moderat

• In this review we aim

  2021-10-25

  

  In this review, we aim to provide a comprehensive understanding of: 1) how AT-resident CD4+ T cell subpopulations regulate the metabolic status of AT; and 2) how adipocytes as antigen presenting cells to modulate the activities of CD4+ T cell subpopulations in AT. Under condition with obesity, ad

• The average pregnancy rate in this work

  2021-10-25

  

  The average pregnancy rate in this work was 60.1%; similar results have been reported with the same estrus synchronization treatment (58% pregnancy rate) [26]. Later studies also showed that the pregnancy rate was 56.9 and 51.1%, with FTAI and estrous detection, respectively [34,35]. Although that t

• The rapid actions of glucocorticoids range from the

  2021-10-25

  

  The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune cudc 907 [12], [13], [14]. Many different kinase signaling pathways have been implicated in the rapid actions of

• The identification of distinct expression domains in the lim

  2021-10-25

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

16347 records 585/1090 page Previous Next First page 上5页 581582583584585 下5页 Last page